BOC-2-AMINO-6-FLUOROBENZOIC ACID

BOC-2-AMINO-6-FLUOROBENZOIC ACID - Names and Identifiers

Name	Boc-2-amino-6-fluorobenzoic acid
Synonyms	BOC-2-AMINO-6-FLUOROBENZOIC ACID Boc-2-amino-6-fluorobenzoic acid 2-((tert-Butoxycarbonyl)amino)-6-fluorobenzoic acid Benzoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-6-fluoro-
CAS	1048919-15-8

BOC-2-AMINO-6-FLUOROBENZOIC ACID - Physico-chemical Properties

Molecular Formula	C12H14FNO4
Molar Mass	255.24
Density	1.307±0.06 g/cm3(Predicted)
Boling Point	317.9±32.0 °C(Predicted)
pKa	2.77±0.36(Predicted)
Storage Condition	2-8°C
Sensitive	Irritant
MDL	MFCD02682192

BOC-2-AMINO-6-FLUOROBENZOIC ACID - Risk and Safety

Hazard Class

IRRITANT

BOC-2-AMINO-6-FLUOROBENZOIC ACID - Introduction

Boc-2-amino-6-fluorobenzoic acid(Boc-2-amino-6-fluorobenzoic acid) is an organic compound. Its properties are as follows:

1. appearance: solid, white crystalline powder.
2. melting point: about 180-186 ℃.
3. Solubility: Soluble in organic solvents (such as ethanol, dimethyl sulfoxide, etc.).
4. chemical structure: it consists of a tert-butoxycarbonyl (Boc, also known as tert-butoxycarbonyl, t-Boc) group and an amino group connected with a fluorobenzoic acid group.

Boc-2-Amino -6-fluorobenzoic acid is commonly used in organic synthesis and has the following applications and uses:

1. as a drug synthesis intermediate: can be used for the synthesis of drugs, drug candidate compounds.
2. for steel surface coating: can be used as a steel surface treatment agent to improve the corrosion resistance of steel.
3. other applications: such as organic synthesis reaction of the protecting group, used to protect the amino (or carboxyl).

The method of preparing Boc-2-amino -6-fluorobenzoic acid usually involves the following steps:

1. synthesis of N-(tert-Butoxycarbonyl)-2-amino-6-fluorobenzamide: firstly, 2-amino-6-fluorobenzoic acid and tert-butoxycarbonyl anhydride (I. e. Boc2O) react under alkaline conditions to generate tert-butyl Boc-2-amino-6-fluorobenzoate. The desired product is then formed by heating the ester to react with anhydrous sphincter water under alkaline conditions.

2. acid hydrolysis of the product: using acidic conditions (such as dilute hydrochloric acid solution), the tert-butoxycarbonyl (Boc) protecting group can be removed from the product by hydrolysis to obtain Boc-2-amino -6-fluorobenzoic acid.

Regarding safety information, Boc-2-amino -6-fluorobenzoic acid is a chemical reagent and must be handled in accordance with laboratory standards. The following are general considerations:

1. Avoid direct contact with skin and eyes: Wear appropriate personal protective equipment, such as lab gloves and safety glasses.
2. Fire hazard: The compound itself is not easy to cause a fire, but it may burn near the fire source.
3. Placement and storage: should be placed in a dry, cool place, and away from fire and flammable materials.

In summary, Boc-2-amino-6-fluorobenzoic acid is an organic compound commonly used in applications such as pharmaceutical synthesis intermediates and steel surface coatings. In the use and storage, should pay attention to safety protection.

Last Update：2024-04-09 20:02:46